{
  "id": 146732,
  "title": "Curious about situation when 3 Gleason pattern is observed",
  "url": "/competitions/prostate-cancer-grade-assessment/discussion/146732",
  "author_name": "Wees Jun",
  "post_date": "2020-04-28T09:49:41.353000",
  "votes": 0,
  "comment_count": 2,
  "views": 0,
  "content": "<p>Hi, from Wiki  'If three patterns are seen, the first number of the score would be the primary grade and the second number the pattern with the highest grade. For example, if the primary tumor grade was 2 and the secondary tumor grade was 3 but some cells were found to be grade 4, the Gleason score would be 2+4=6.' \n<a href=\"https://en.wikipedia.org/wiki/Gleason_grading_system\">https://en.wikipedia.org/wiki/Gleason_grading_system</a></p>\n\n<p>I would like to know if the 3 patterns or even more patterns observed situation exists in our dataset. If so, does it follow the rule in Wiki?</p>",
  "messages": [
    {
      "id": 824522,
      "postDate": "2020-04-28T12:29:18.997Z",
      "content": "<p>Good question. As a note, Gleason growth patterns 1 and 2 are not or rarely reported anymore on biopsies. This is not mentioned on the Wikipedia page. In our dataset you will see that only growth patterns 3, 4 and 5 are reported.</p>\n\n<p>Copied from a another post by me:</p>\n\n<blockquote>\n  <p>In some cases, there are three patterns present. For example, 60% Gleason 3, 30% Gleason 4, and 10% Gleason 5. In those edge cases, the grading system states that the higher Gleason pattern should be used. So, in this case: 3+5 (even though %G5 &lt; %G4) with an ISUP score of 4. This is important because such a minor aggressive component can have a worse prognosis. (Full comment here: <a href=\"https://www.kaggle.com/c/prostate-cancer-grade-assessment/discussion/145027#821584\">https://www.kaggle.com/c/prostate-cancer-grade-assessment/discussion/145027#821584</a>)</p>\n</blockquote>\n\n<p>To answer your question: Yes, if three patterns are present, the rule is applied given that it is at least 5%. See more info on the <a href=\"https://www.kaggle.com/c/prostate-cancer-grade-assessment/overview/additional-resources\">additional resources page</a>.</p>",
      "rawMarkdown": "Good question. As a note, Gleason growth patterns 1 and 2 are not or rarely reported anymore on biopsies. This is not mentioned on the Wikipedia page. In our dataset you will see that only growth patterns 3, 4 and 5 are reported.\n\nCopied from a another post by me:\n\n&gt; In some cases, there are three patterns present. For example, 60% Gleason 3, 30% Gleason 4, and 10% Gleason 5. In those edge cases, the grading system states that the higher Gleason pattern should be used. So, in this case: 3+5 (even though %G5 &lt; %G4) with an ISUP score of 4. This is important because such a minor aggressive component can have a worse prognosis. (Full comment here: https://www.kaggle.com/c/prostate-cancer-grade-assessment/discussion/145027#821584)\n\nTo answer your question: Yes, if three patterns are present, the rule is applied given that it is at least 5%. See more info on the [additional resources page](https://www.kaggle.com/c/prostate-cancer-grade-assessment/overview/additional-resources).",
      "votes": 1,
      "replies": [
        {
          "id": 826956,
          "postDate": "2020-04-30T01:31:04.950Z",
          "content": "<p>Thanks for explanation. Appreciate helpful answer!</p>",
          "rawMarkdown": "Thanks for explanation. Appreciate helpful answer!"
        }
      ]
    },
    {
      "id": 824314,
      "postDate": "2020-04-28T09:49:41.353Z",
      "content": "<p>Hi, from Wiki  'If three patterns are seen, the first number of the score would be the primary grade and the second number the pattern with the highest grade. For example, if the primary tumor grade was 2 and the secondary tumor grade was 3 but some cells were found to be grade 4, the Gleason score would be 2+4=6.' \n<a href=\"https://en.wikipedia.org/wiki/Gleason_grading_system\">https://en.wikipedia.org/wiki/Gleason_grading_system</a></p>\n\n<p>I would like to know if the 3 patterns or even more patterns observed situation exists in our dataset. If so, does it follow the rule in Wiki?</p>",
      "rawMarkdown": "Hi, from Wiki  'If three patterns are seen, the first number of the score would be the primary grade and the second number the pattern with the highest grade. For example, if the primary tumor grade was 2 and the secondary tumor grade was 3 but some cells were found to be grade 4, the Gleason score would be 2+4=6.' \nhttps://en.wikipedia.org/wiki/Gleason_grading_system\n\nI would like to know if the 3 patterns or even more patterns observed situation exists in our dataset. If so, does it follow the rule in Wiki?"
    }
  ],
  "comments": [
    {
      "id": 824522,
      "author_name": "Wouter Bulten",
      "author_url": "",
      "post_date": "2020-04-28T12:29:18.997000",
      "content": "<p>Good question. As a note, Gleason growth patterns 1 and 2 are not or rarely reported anymore on biopsies. This is not mentioned on the Wikipedia page. In our dataset you will see that only growth patterns 3, 4 and 5 are reported.</p>\n\n<p>Copied from a another post by me:</p>\n\n<blockquote>\n  <p>In some cases, there are three patterns present. For example, 60% Gleason 3, 30% Gleason 4, and 10% Gleason 5. In those edge cases, the grading system states that the higher Gleason pattern should be used. So, in this case: 3+5 (even though %G5 &lt; %G4) with an ISUP score of 4. This is important because such a minor aggressive component can have a worse prognosis. (Full comment here: <a href=\"https://www.kaggle.com/c/prostate-cancer-grade-assessment/discussion/145027#821584\">https://www.kaggle.com/c/prostate-cancer-grade-assessment/discussion/145027#821584</a>)</p>\n</blockquote>\n\n<p>To answer your question: Yes, if three patterns are present, the rule is applied given that it is at least 5%. See more info on the <a href=\"https://www.kaggle.com/c/prostate-cancer-grade-assessment/overview/additional-resources\">additional resources page</a>.</p>",
      "votes": 1,
      "replies": [
        {
          "id": 826956,
          "author_name": "Wees Jun",
          "author_url": "",
          "post_date": "2020-04-30T01:31:04.950000",
          "content": "<p>Thanks for explanation. Appreciate helpful answer!</p>",
          "votes": 0,
          "replies": []
        }
      ]
    }
  ],
  "raw_markdown_by_id": {
    "824522": "Good question. As a note, Gleason growth patterns 1 and 2 are not or rarely reported anymore on biopsies. This is not mentioned on the Wikipedia page. In our dataset you will see that only growth patterns 3, 4 and 5 are reported.\n\nCopied from a another post by me:\n\n&gt; In some cases, there are three patterns present. For example, 60% Gleason 3, 30% Gleason 4, and 10% Gleason 5. In those edge cases, the grading system states that the higher Gleason pattern should be used. So, in this case: 3+5 (even though %G5 &lt; %G4) with an ISUP score of 4. This is important because such a minor aggressive component can have a worse prognosis. (Full comment here: https://www.kaggle.com/c/prostate-cancer-grade-assessment/discussion/145027#821584)\n\nTo answer your question: Yes, if three patterns are present, the rule is applied given that it is at least 5%. See more info on the [additional resources page](https://www.kaggle.com/c/prostate-cancer-grade-assessment/overview/additional-resources).",
    "824314": "Hi, from Wiki  'If three patterns are seen, the first number of the score would be the primary grade and the second number the pattern with the highest grade. For example, if the primary tumor grade was 2 and the secondary tumor grade was 3 but some cells were found to be grade 4, the Gleason score would be 2+4=6.' \nhttps://en.wikipedia.org/wiki/Gleason_grading_system\n\nI would like to know if the 3 patterns or even more patterns observed situation exists in our dataset. If so, does it follow the rule in Wiki?"
  }
}